Can Men Preserve Their Sperm?

Sperm Cryopreservation in Men

Can Men Preserve Their Sperm?

Sperm Cryopreservation in Men

Sperm cryopreservation can be offered regularly to all male patients undergoing gonadotoxic treatment. When patients recover, assisted reproductive technologies (ART) such as ICSI can then be used to give patients a better chance of conceiving their own children.

Spermatogenesis In Men

In children and adults, chemotherapy and radiotherapy, even at low doses, can have a negative impact on the seminiferous epithelium and interfere with spermatogenesis and testicular function. Cytotoxic therapy has a reversible effect on spermatogenesis, but in some cases, it may be a permanent one. Germ cells are very irradiation-sensitive. While radiotherapy changes the sperm concentration, irradiation further interferes with sperm DNA.

sperm cryopreservation

Impact of Chemotherapy

Currently, the effectiveness of anticancer treatments improved the survival rates tremendously; as a result, most of the patients are cured successfully. The quality of life has now become a critical factor, including posttreatment fertility status. However, depending on the dosage and type of drugs used, radiotherapy and chemotherapy can produce gonadal toxicity ranging from temporary oligozoospermia to permanent azoospermia.

Gonadotoxic Embryo Exposure

Around 50 percent of conception-related issues are either entirely caused by male infertility or are combined with problems on the female side. Exposures result from lifestyle habits, medicines, and malignancy care, as well as occupational and environmental hazards. Regardless of the path, the effect on subsequent fertility of paternal exposure to gonadotoxins is important, as it not only affects a man, but may also affect his potential offspring.

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sperm cryopreservation

Sperm Banking

Testicular Sperm Collection

sperm cryopreservation
sperm cryopreservation

Germ Cells Transplantation

Spermatogonial Stem Cells

Isolation, maintenance and differentiation of spermatogonial stem cells (SSCs) form the next step in male fertility to restore spermatogenesis and use SSCs in assisted reproduction. Since a small amount of tissue is collected by means of biopsy, the propagation of SSCs in vitro to repopulate the testis becomes very important. The methodology developed in human SSCs and germ cells (GCs) is very recent, and further research is needed.

sperm cryopreservation